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Abstract Heat shock factor 1 (HSF1) is a stress-responsive transcription factor that promotes cancer cell malignancy. To provide a better understanding of the biological processes regulated by HSF1, here we developed an HSF1 activity signature (HAS) and found that it was negatively associated with antitumor immune cells in breast tumors. Knockdown of HSF1 decreased breast tumor size and caused an influx of several antitumor immune cells, most notably CD8+ T cells. Depletion of CD8+ T cells rescued the reduction in growth of HSF1-deficient tumors, suggesting HSF1 prevents CD8+ T-cell influx to avoid immune-mediated tumor killing. HSF1 suppressed expression of CCL5, a chemokine for CD8+ T cells, and upregulation of CCL5 upon HSF1 loss significantly contributed to the recruitment of CD8+ T cells. These findings indicate that HSF1 suppresses antitumor immune activity by reducing CCL5 to limit CD8+ T-cell homing to breast tumors and prevent immune-mediated destruction, which has implications for the lack of success of immune modulatory therapies in breast cancer. Significance:The stress-responsive transcription factor HSF1 reduces CD8+ T-cell infiltration in breast tumors to prevent immune-mediated killing, indicating that cellular stress responses affect tumor-immune interactions and that targeting HSF1 could improve immunotherapies. 

Josephson junctions (JJs) with Josephson energy EJ≲1 K are widely employed as non-linear elements in superconducting circuits for quantum computing operating at milli-Kelvin temperatures. In the qubits with small charging energy EC ( EJ/EC≫1 ), such as the transmon, the incoherent phase slips (IPS) might become the dominant source of dissipation with decreasing EJ. In this work, a systematic study of the IPS in low-EJ JJs at milli-Kelvin temperatures is reported. Strong suppression of the critical (switching) current and a very rapid growth of the zero-bias resistance due to the IPS are observed with decreasing EJ below 1 K. With further improvement of coherence of superconducting qubits, the observed IPS-induced dissipation might limit the performance of qubits based on low-EJ junctions. These results point the way to future improvements of such qubits. 

Fast radio bursts (FRBs) are highly dispersed millisecond-duration radio bursts,^[1,2]of which the physical origin is still not fully understood. FRB 20201124A is one of the most actively repeating FRBs. In this paper, we present the collection of 1863 burst dynamic spectra of FRB 20201124A measured with the Five-hundred-meter Aperture Spherical radio Telescope (FAST). The current collection, taken from the observation during the FRB active phase from April to June 2021, is the largest burst sample detected for any FRB so far. The standard PSRFITs format is adopted, including dynamic spectra of the burst, and the time information of the dynamic spectra, in addition, mask files help readers to identify the pulse positions are also provided. The dataset is available in Science Data Bank, with the linkhttps://www.doi.org/10.57760/sciencedb.j00113.00076.